New preprint: Establishing epidemiological cutoffs for the CRyPTIC UKMYC microdilution plates.

The CRyPTIC project has measured the minimum inhibitory concentrations (MICs) of 20,637 isolates to 13 different anti-TB drugs using a bespoke 96-well broth microdilution plate. These samples were collected by 14 partner laboratories based in 11 countries and span five continents. 

In this preprint, we use this large dataset to determine epidemiological cutoffs (ECOFF or ECV) for each of the 13 compounds. Although many of the analyses being undertaken by the consortium use the MIC, we also would like to be able to classify each isolate as susceptible or resistant to each of the 13 antibiotics.