Category: news
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New CRyPTIC datasets
The original CRyPTIC publications were based on a dataset resulting from a data freeze in April 2020. This dataset (v1.1.1) could be downloaded via an FTP site. Since then the consortium has continued to receive additional samples and data from its members and there have been a number of improvements to how both the genetic…
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CRyPTIC ECOFF/ECV paper attracts two letters
The paper we, as a consortium, published last year in Eur Rest J, described the ECOFF/ECV values we had determined for research use. The Editor received two letters about our paper which you can read here and here. Our response is here.
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Two new publications: Data compendium and GWAS
These two papers, just published in PLoS Biology, are amongst the primary research outputs of the CRyPTIC project. The first, entitled “A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics” describes in detail the large dataset of clinical tuberculosis isolates collected by CRyPTIC, including examining the probability of a sample…
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CRyPTIC papers covered by CIDRAP
The Center for Infectious Disease Research and Policy (CIDRAP) has written a news story on the two CRyPTIC papers recently published in PLoS Biology. Click here to read more.
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New publication: BashTheBug!
We enlisted citizen scientists to help us classify the many thousands of photographs of the different samples of M. tuberculosis collected by CRyPTIC growing on different concentrations of antibiotics by launching the BashTheBug project on the Zooniverse platform back in April 2017. In this paper, published in eLife, we investigate how to form a consensus from the many classifications made by the volunteers and…
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Interview on the BBC World Service
You can hear the CRyPTIC Principal Investigator, Prof Derrick Crook, talking about the project and its impact on tuberculosis on News Hour on the BBC World Service here. The segment starts about 35 minutes in. You will need a BBC login so this link may not work for everyone.
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Read in the Economist about CRyPTIC
Hot on the heels of the press release, the Economist have published an article describing the work of the CRyPTIC project. Note that it is behind a pay wall, but you can always buy a copy of the print edition when it comes out on Friday 23 October 2021!
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Press release – Largest ever global study of tuberculosis identifies genetic causes of drug resistance
Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common tuberculosis (TB) drug treatments. The Comprehensive Resistance Prediction for Tuberculosis International Consortium (CRyPTIC) research project has collected the largest ever global dataset of clinical M. tuberculosis samples…
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New logo celebrating the release of the CRyPTIC papers
To celebrate the release of the CRyPTIC dataset and the nine manuscripts deposited in preprint servers, we’ve made a new CRyPTIC logo that includes all the names of the people in the CRyPTIC project.
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New publication: Structure of MmpL3 protein
Oliver Adams, as part of his DPhil studies in Simon Newstead’s group at the University of Oxford, has resolved the structure of MmpL3 which is the only essential member of the mmpL family of genes. It is a mycolic acid transporter that is targeted by a number of antituberculars under active development, for example SQ109 which is in Phase 3 clinical trials. This…