News
RESPECT-TB launched!
13 Sep 2026
A new international programme, funded by Wellcome, will study multi-drug resistance tuberculosis (MDR-TB) in five countries; India, Kazakhstan, Mozambique, South Africa and Vietnam.
New dataset released (v3.4.1)
12 Sep 2026
A new version of the CRyPTIC dataset (v3.4.1) has been made available on Zenodo today; it adds 53,916 VCF files and 53,975 FASTA files to the dataset, all the data tables are unchanged.
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23 Jun 2026
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New CRyPTIC datasets
30 Apr 2025
The original CRyPTIC publications were based on a dataset resulting from a data freeze in April 2020.
CRyPTIC ECOFF/ECV paper attracts two letters
11 May 2023
The paper we, as a consortium, published last year in Eur Rest J, described the ECOFF/ECV values we had determined for research use.
Two new publications: Data compendium and GWAS
16 Aug 2022
These two papers, just published in PLoS Biology, are amongst the primary research outputs of the CRyPTIC project.
CRyPTIC papers covered by CIDRAP
16 Aug 2022
The Center for Infectious Disease Research and Policy (CIDRAP) has written a news story on the two CRyPTIC papers recently published in PLoS Biology.
New publication: BashTheBug!
27 May 2022
We enlisted citizen scientists to help us classify the many thousands of photographs of the different samples of M. tuberculosis collected by CRyPTIC growing on different concentrations of antibiotics by launching the BashTheBug project on the Zooniverse platform back in April 2017.
New logo celebrating the release of the CRyPTIC papers
19 Oct 2021
To celebrate the release of the CRyPTIC dataset and the nine manuscripts deposited in preprint servers, we’ve made a new CRyPTIC logo that includes all the names of the people in the CRyPTIC project.
Press release – Largest ever global study of tuberculosis identifies genetic causes of drug resistance
19 Oct 2021
Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common tuberculosis (TB) drug treatments.
Read in the Economist about CRyPTIC
19 Oct 2021
Hot on the heels of the press release, the Economist have published an article describing the work of the CRyPTIC project.
Interview on the BBC World Service
19 Oct 2021
You can hear the CRyPTIC Principal Investigator, Prof Derrick Crook, talking about the project and its impact on tuberculosis on News Hour on the BBC World Service here.
New publication: Structure of MmpL3 protein
9 Jul 2021
Oliver Adams, as part of his DPhil studies in Simon Newstead’s group at the University of Oxford, has resolved the structure of MmpL3 which is the only essential member of the mmpL family of genes.
WHO tuberculosis mutation catalogue released
28 Jun 2021
Last Friday 25 June 2021, the World Health Organization released their first report containing a catalogue of mutations in Mycobacterium tuberculosis and their association with drug resistance.
Internal project seminars in June 2021
27 May 2021
The analysis group will be presenting five consecutive seminars starting on Wed 9 June at 1500 BST (1400 GMT).
New preprint: Deciphering bedaquiline and clofazimine resistance in tuberculosis
22 Mar 2021
Stefan Niemann, a CRyPTIC partner, led this combined experimental and modelling study looking at how resistance is conferred to bedaquline and clofazimine in Mycobacterial tuberculosis.
New preprint: Establishing epidemiological cutoffs for the CRyPTIC UKMYC microdilution plates.
2 Mar 2021
The CRyPTIC project has measured the minimum inhibitory concentrations (MICs) of 20,637 isolates to 13 different anti-TB drugs using a bespoke 96-well broth microdilution plate.
BashTheBug passes 4 million classifications
30 Jun 2020
A few days ago our BashTheBug volunteers passed the 4 million classifications mark!
New paper: Estimating genetic adaption in 10,000 M. tuberculosis genomes
26 Mar 2020
Daniel Wilson, one of the CRyPTIC partners, has recently published a paper where he introduces a new approach, genomegaMap, which estimates the ratio of non-synonymous to synonymous mutations (usually referred to as dN/dS) at sites across the genome.
CRyPTIC inoculates its 15,000th microtitre plate
18 Dec 2019
Sometime in November 2019, the 15,000th 96-well microtitre plate was inoculated with M. tuberculosis.
Fifth Annual CRyPTIC Meeting in Hyderabad
7 Nov 2019
The fifth CRyPTIC annual meeting took place in Hyderabad on Sat 26 and Sun 27 Oct 2019.
Groundbreaking publication
24 Oct 2018
Groundbreaking publication in NEJM on using DNA sequencing for drug resistance prediction in TB.
BBC video shining light on the deadliest of infectious diseases: TB
22 Dec 2017
BashTheBug wins digital award!
11 Sep 2017
The UK’s National Institute for Health Research (NIHR) announced that BashTheBug is the winner for the online community category in the “Let’s Get Digital” competition.